Human Adipose-Derived Stem Cells (hADSCs) or Stromal Vascular Fraction (SVF) derived from adipose tissue play a crucial role in enhancing the regenerative properties of fat grafting. These stem cells contribute to the structural integrity and longevity of transplanted fat while improving the three-dimensional architecture of the reticular dermis and the microvascular bed. By promoting angiogenesis and enhancing tissue integration, they help maintain graft volume, improve skin texture, and accelerate healing processes.

Furthermore, research has demonstrated that hADSCs actively secrete a variety of beneficial growth factors, including vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and platelet-derived growth factor (PDGF), all of which play a vital role in tissue repair and regeneration. These factors stimulate fibroblast activity, enhance extracellular matrix production, and significantly increase collagen synthesis, which in turn strengthens skin elasticity and reduces the appearance of wrinkles.

Beyond aesthetic applications, ADSC transplantation has shown promising results in reversing skin aging at a cellular level by restoring dermal thickness and improving hydration. Additionally, clinical studies suggest that hADSC therapy can enhance muscle regeneration and improve overall physical strength in aging individuals, promoting better mobility and quality of life. The cumulative effects of stem cell transplantation highlight its potential as a powerful tool for rejuvenation, both in dermatological and regenerative medicine applications.