Anti-inflammatory and regenerative potentials of stem cells have been utilised in the treatment of digestive system diseases. Stem cell treatment has been shown effective in the treatment of liver failure and Chron’s disease. Injection of hADSCs has been shown beneficial in the closure of perianal fistula in Chron’s patients and during repair surgery for fecal incontinence where it has improved contractile function.

References:

Damian (2009) Expanded Adipose-Derived Stem Cells for the Treatment of Complex Perianal Fistula: a Phase II Clinical Trial. Diseases of the Colon & Rectum: 52 (1): 79-86, doi: 10.1007/DCR.0b013e3181973487.

Fagoonee et al (2016) Prospects for Adult Stem Cells in the Treatment of Liver Diseases. Stem Cells and Development 25 (20). DOI: 10.1089/scd.2016.0144

Lee at al (2013) Autologous Adipose Tissue-derived Stem Cells Treatment Demonstrated Favorable and Sustainable Therapeutic Effect for Crohn’s Fistula. doi:10.1002/stem.1357.

Qiu et al. (2017) Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohn’s disease. Qiu et al. Stem Cell Research & Therapy 8:136, DOI 10.1186/s13287-017-0570-x.

Sarveazad et al (2017) A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial. Stem Cell Research & Therapy 8:40, DOI 10.1186/s13287-017-0489-2.

Wang et al (2017) Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure. Stem Cell Research & Therapy 8:137, DOI 10.1186/s13287-017-0576-4.

Zhang et al (2017) Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure . Stem Cell Research & Therapy 8:70, DOI

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