Stem cell transplantation has shown important role in the pancreatic repair and its functional improvement. Positive metabolic effects have been consistently demonstrated in the literature for MSCs transplantation as a treatment for diabetes. Mesenchymal stem cells, from which a large numbers of cells can be produced, offer a potent starting material for transplantation in diabetic patients.

References:

Cho et al (2018) A review of clinical trials: mesenchymal stem cell transplant therapy in type 1 and type 2 diabetes mellitus. Am J Stem Cells 7(4): 82–93.

Couri and Voltarelli, (2009) Stem cell therapy for type 1 diabetes mellitus: a review of recent clinical trials. Diabetol Metab Synd. 1 (1): 19

Thakkar et al (2015) Insulin-secreting adipose-derived mesenchymal stromal cells with bone marrow derived hematopoietic stem cells from autologous and allogenic sources for type 1 diabetes mellitus. Cytotherapy 17: 940-947.

Xu et al (2008) Mesenchymal stem cell therapy for diabetes through paracrine mechanisms. Medical Hypotheses (2008) 71, 390–393

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