SBS | Research & Development

Research and Development

SBS’ research program is based on utilisation of the paracrine effect of stem cells. Our own experimental results and many other researchers’ show that paracrine effect is a major component of the regenerative effect of transplanted stem cells. Paracrine effect is exerted via secretomes of stem cells. A major component of the secretomes are Extracellular Vesicles (EVs).

Besides manufacturing clinical grade stem cells, SBS pursues research and development in the domain of stem cells in order to create new cell therapy based modalities for human medical use. Adipose tissue derived stem cells (ADSCs) are self renewing cells that can differentiate to many other cell types. This makes ADSCs attractive starting material for developing cell based treatments for regenerative medicine applications. After transplantation the engrafted multipotent stem cells differentiate into different cell types and regenerate the damaged tissue. Alternatively, some secretomes of transplanted stem cells stimulates the endogenous stem cells that repair the damaged cells. This signaling from one cell to another is called the paracrine effect; the action of the secretion of one kind of cell on another kind. In fact paracrine effect acts by regenerating the damaged host tissue without direct engrafting of the the transplanted cells. Many different cell types, including adipose tissue derived stem cells, can invoke a paracrine response that result in activation of host stem cells after transplantation.

Extracellular Vesicles (EVs)

EVs are small cargo-carrying vesicles released by cells into the extracellular space.
EVs are membrane bound particles packed with cytokines, regulatory proteins, DNA and RNAs.
EV load can be changed for specific purpose by pre-conditioning the stem cells.
Unlike live cells, EV-based products do not have the limitations of storage.
EV-based products can be stored as off-the-shelf products.
Diagnostic and therapeutic potentials of EVs are the subject of many research programs at many centres including ours..

Extracellular Vesicles (EVs) are small cargo-carrying vesicles released by cells to the extracellular space, which can be utilized and loaded for specific purpose by preconditioning the stem cells, offering great diagnostic and therapeutic potential.

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Towards Allograft Longevity: Leveraging Omics Technologies to Improve Heart Transplant Outcomes - Scientific Figure on ResearchGate.

Exosome

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The Company

Swiss Bioscience GmbH (SBS) was established in 2014 in Switzerland and is specialized in producing pharmaceutical quality grade stems cells under cGMP* conditions. The cells are isolated from human adipose tissue to produce stromal vascular fraction (SVF) which is then purified and expanded to produce human adipose tissue derived stem cells (hADSCs).

The hADSC and SVF provided by SBS may only be used as a transplant product within the framework of a valid marketing authorization or within the framework of controlled clinical trials.

SBS pursues research and development in the domain of stem cells, create new cell therapy based modalities for human medical use. SBS’ research program is based on utilisation of the paracrineeffect of stem cells and is aimed at developing therapeutics from extracellular vesicles extracted from stem cells.