Extracellular Vesicles (EVs)

  • EVs are small cargo-carrying vesicles released by cells into the extracellular space.
  • EVs are membrane bound particles packed with cytokines, regulatory proteins, DNA and RNAs.
  • EV load can be changed for specific purpose by pre-conditioning the stem cells.
  • Unlike live cells, EV-based products do not have the limitations of storage.
  • EV-based products can be stored as off-the-shelf products.
  • Diagnostic and therapeutic potentials of EVs are the subject of many research programs at many centres including ours..

SBS is currently involved in research on developing EV-based products for the treatment of Psoriasis, Antiageing, Arthritis, Chronic wounds.

Independent Publications about EVs:

Lin L. and Du L., The role of secreted factors in stem cells-mediated immune regulation. Cellular Immunology (2018) 326:24
Phan J et al. , Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy. Journal of Extracellular Vesicles (2018) 7:1
Pomatto M. A. C. et al, Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases. International Journal of Endocrinology (2018) Article ID 4302096

Nawaz, Muhammad. (2015). Introduction to extracellular vesicles (Exosomes and microvesicles) and clinical implications.